Netrin-1 promotes epithelium repair in corneal injury
نویسندگان
چکیده
منابع مشابه
Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney.
Endogenous mechanisms exist to limit inflammation. One such molecule is netrin. This study examined the impact of ischemia-reperfusion (I/R) on netrin expression and the role of netrin in preventing renal inflammation and injury. All three isoforms of netrin (1, 3, and 4) are expressed in normal kidney. I/R significantly downregulated netrin-1 and -4 mRNA expression, whereas expression of netri...
متن کاملNetrin-1 and kidney injury. II. Netrin-1 is an early biomarker of acute kidney injury.
Acute kidney injury is an important complication in hospitalized patients often diagnosed late and associated with high mortality and morbidity. Although biomarkers for nephrotoxicity are available, they often lack sensitivity and specificity for detecting tubular injury. Netrin-1 is a laminin-like molecule highly expressed in many organs including kidney. To determine the value of netrin-1 as ...
متن کاملAlpha 1-adrenoceptors in human corneal epithelium.
Specific binding of the potent, selective alpha 1-adrenoceptor antagonist 3H-prazosin was demonstrated in cultured human corneal epithelial cells. Specific binding of the radioligand was concentration-dependent between 0.5 and 6 nM, with apparent saturation of receptor sites seen at higher concentrations. The cells exhibited a maximum binding capacity for 3H-prazosin of 225 fmol/mg of cellular ...
متن کاملNetrin-1 simultaneously suppresses corneal inflammation and neovascularization.
PURPOSE To investigate the effect of netrin-1 on alkali burn-induced corneal inflammation and neovascularization. METHODS The expression of netrin-1 and its receptors UNC5A, UNC5B, UNC5C, UNC5D, adenosine 2b receptor (A2BAR), deleted in colorectal cancer (DCC), and neogenin in normal and alkali-burned rat cornea were determined by RT-PCR and/or Western blot analysis, or immunostaining. Topica...
متن کاملNotch signaling promotes the corneal epithelium wound healing
PURPOSE The Notch signaling pathway plays crucial roles in regulation of cell proliferation, differentiation and cell fate decision in multiple tissues and cell types. This study was designed to test the effects of enhanced Notch activity on corneal epithelium homeostasis and wound healing using the transgenic mice that overexpressed an activated Notch1 (NICD) in cornea epithelium. METHODS Th...
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ژورنال
عنوان ژورنال: International Journal of Ophthalmology
سال: 2020
ISSN: 2222-3959,2227-4898
DOI: 10.18240/ijo.2020.02.02